Product Name: P-Phenylenediamine (Also known as 1,4-Phenylenediamine, Para-phenylenediamine, PPD)
Chemical Formula: C6H8N2
CAS Number: 106-50-3
EC Number: 203-404-7
Use: Intermediate for dyes, hair colorants, rubber antioxidants, and photographic developer
Manufacturer/Supplier: Listed on label or invoice — always check the latest company contact information
Emergency Contact Number: Refer to your facility's emergency action plan or national poison control center
GHS Classification: Acute toxicity – Oral (Category 3), Acute toxicity – Dermal (Category 3), Skin sensitization (Category 1), Eye irritation (Category 2), Specific Target Organ Toxicity (Repeated Exposure, Category 2)
Signal Word: Danger
Hazard Statements: Toxic if swallowed, toxic in contact with skin, may cause allergic skin reaction, causes serious eye irritation, may cause damage to organs through prolonged or repeated exposure
Pictograms: Skull and crossbones, health hazard, exclamation mark
Routes of Exposure: Skin contact, eye contact, inhalation, ingestion
Acute Effects: Allergic reactions, respiratory distress, skin burns, nausea, vomiting
Chronic Effects: Kidney damage, respiratory issues, skin sensitization
Chemical Identity: P-Phenylenediamine
Molecular Weight: 108.14 g/mol
Component: PPD — 99%+
Impurities: Less than 1% (trace stabilizers and residual solvents)
Inhalation: Move person to fresh air, keep at rest, seek medical attention if symptoms persist, support breathing if necessary
Skin Contact: Remove contaminated clothing, wash skin thoroughly with soap and water, avoid harsh scrubbing, seek immediate medical advice, monitor for allergic reactions or rash
Eye Contact: Rinse cautiously with water for at least 15 minutes, remove contact lenses if present and easy to do, continue rinsing, get prompt medical evaluation
Ingestion: Rinse mouth with water, do not induce vomiting, do not give anything by mouth to an unconscious person, seek immediate medical help
Most Important Symptoms: Respiratory distress, skin redness or blistering, eye irritation, gastrointestinal upset, allergic reactions
Suitable Extinguishing Media: Dry chemical, carbon dioxide, alcohol-resistant foam, water spray (not a straight stream)
Unsuitable Extinguishing Media: Avoid high-pressure water jets and direct water streams
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, nitrogen oxides, toxic fumes
Special Equipment: Full protective gear including self-contained breathing apparatus (SCBA), chemical-resistant clothing
Fire & Explosion Hazards: Dust may form explosive mixture with air, toxic gases produced under fire conditions
Personal Precautions: Evacuate area, ventilate, avoid dust generation, wear chemical-resistant gloves, protective clothing, and eye protection
Environmental Precautions: Prevent entry into sewers and waterways, contain spill where possible, notify environmental authorities for large spills
Methods for Cleanup: Collect spillage using non-sparking tools, place in a properly labeled chemical waste container, minimize dust, seal containers for disposal, clean spill area with water and detergent
Precautions for Safe Handling: Avoid contact with skin, eyes, and clothing, do not inhale dust or fumes, work in well-ventilated areas, use closed processes when available, handle in accordance with good industrial hygiene and safety practices, wash hands thoroughly after handling
Storage Conditions: Store in tightly sealed containers, in a cool, dry, and well-ventilated place, keep away from direct sunlight, incompatible substances, and sources of ignition, do not store with strong oxidizing agents or acids
Packaging Materials: Use corrosion-resistant and properly labeled containers, prevent contamination from getting into receptacles
Occupational Exposure Limits: ACGIH TLV: 0.1 mg/m³ (skin), OSHA PEL: Not established, always refer to local regulations
Engineering Controls: Use local exhaust or general ventilation, enclose handling processes if possible, provide safety showers and eye wash stations
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), protective clothing with long sleeves, safety goggles or face shield, particulate respirator (NIOSH approved) for dust exposure
Hygiene Measures: Avoid eating, drinking, or smoking near work area, wash thoroughly after handling, ensure work clothing is regularly washed, dispose of contaminated materials properly
Appearance: White to purple-gray crystals or powder, turns brown on air exposure
Odor: Faint, aromatic
Melting Point: 137-140°C
Boiling Point: 267°C (decomposes)
Solubility: Moderately soluble in water (25.7g/L at 20°C), soluble in alcohol and ether
Density: 1.2 g/cm³
pH: Slightly basic (in aqueous solution)
Vapor Pressure: Practically nonvolatile at room temperature
Partition Coefficient (log Pow): -0.30
Chemical Stability: Stable under recommended storage conditions, reacts with oxygen leading to color change
Possibility of Hazardous Reactions: May react vigorously with oxidizing agents, acids, organic peroxides, and halogens
Conditions to Avoid: Heat, flames, sparks, incompatible materials, prolonged exposure to air
Incompatible Materials: Strong oxidizers, acids, acyl chlorides, acid anhydrides, halogens
Decomposition Products: Carbon oxides, nitrogen oxides, aniline, related amines, toxic fumes
Acute Toxicity: Oral LD50 (rat): 80 mg/kg; Dermal LD50 (rabbit): 794 mg/kg
Inhalation Toxicity: No reliable data, but inhalation of dust may cause respiratory irritation
Skin Corrosion/Irritation: Causes skin irritation and sensitization, may produce eczematous dermatitis
Serious Eye Damage/Irritation: Causes serious eye irritation, redness, and pain
Sensitization: Strong skin sensitizer, known cause of allergic reactions upon repeat exposure
Chronic Effects: Kidney and liver toxicity with prolonged or repeated exposure, possible hematologic effects
Carcinogenicity/Mutagenicity/Reproductive Toxicity: Not classified as carcinogenic by IARC, limited evidence of mutagenicity in vitro, reproductive toxicity data inadequate
Ecotoxicity: Toxic to aquatic life, acute and chronic effects observed in fish and invertebrates
Persistence and Degradability: Not readily biodegradable, persists in the environment
Bioaccumulative Potential: Low potential for bioaccumulation (Log Kow -0.30)
Mobility in Soil: High mobility due to water solubility, risk of groundwater contamination
Other Adverse Effects: Hazardous to aquatic environments even at low concentrations, proper precautions needed to avoid environmental release
Waste Disposal Methods: Collect and dispose as hazardous chemical waste according to local, regional, or national regulations; do not release to sewage, rivers, or ground
Container Disposal: Empty containers must be triply rinsed and sent to an approved waste facility, never reuse unwashed containers
Precautions: Do not mix with incompatible substances, avoid unprotected handling during disposal
UN Number: UN 1673
Proper Shipping Name: P-Phenylenediamine
Hazard Class: 6.1 (Toxic substances)
Packing Group: III
Labels Required: Toxic
Special Provisions: Protect containers from physical damage, moisture, and direct sunlight; transport in accordance with national and international regulations
OSHA: Material classified as hazardous, covered under OSHA Hazard Communication Standard
TSCA: Listed on the US Toxic Substances Control Act (TSCA) Inventory
REACH: Complies with EU REACH Regulation; subject to restrictions for use in consumer products, particularly hair dyes
SARA Title III: Subject to reporting under SARA 311/312 (acute/chronic hazards); not subject to Section 313 reporting
California Proposition 65: Not currently listed as a chemical known to cause cancer or reproductive toxicity
Other National/Regional Requirements: Always consult the latest local, regional, and international legislation pertaining to chemical handling, transportation, and disposal
