Product Name: Neopentyl Glycol Diacrylate
Chemical Formula: C14H20O4
SYNONYMS: NPGDA, 2,2-Dimethyl-1,3-Propanediol Diacrylate
CAS Number: 2223-82-7
Recommended Use: Intermediate for resins, coatings, adhesives, inks
Supplier Details: Chemical manufacturer or distributor info on packaging
Emergency Telephone: Chemtrec: +1-800-424-9300
GHS Classification: Skin irritation (Category 2), Eye irritation (Category 2A), Sensitization—skin (Category 1), Specific Target Organ Toxicity (STOT) single exposure (Category 3—respiratory tract irritation)
Signal Word: Warning
Hazard Statements: Causes skin irritation; Causes serious eye irritation; May cause allergic skin reaction; May cause respiratory irritation
Pictograms: Exclamation mark
Routes of Exposure: Inhalation, Skin contact, Eye contact, Ingestion
Most Important Hazards: Can trigger skin rash and discomfort; vapor or mist can bother breathing passages; liquid can injure eyes; can be a hazard in poorly ventilated zones
Component: Neopentyl Glycol Diacrylate
CAS Number: 2223-82-7
Concentration: 95% – 98%
Impurities: Traces of acrylic acid, stabilizer (like MEHQ at <500 ppm), may contain low-level oligomers
Inhalation: Move outside, give fresh air, loosen clothing, get medical attention if symptoms remain
Skin Contact: Remove contaminated clothes, wash skin with plenty of soap and water, seek help if rash or pain persists
Eye Contact: Rinse eyes gently with water for several minutes, remove lenses if present, keep rinsing, see a doctor for lingering pain
Ingestion: Rinse mouth, avoid forcing to vomit, seek immediate care for pain or trouble breathing
Most Important Symptoms: Itching, redness, blisters on skin, watering, burning in eyes, choking or coughing
Advice to Physician: Treat symptomatically; delayed effects possible from skin sensitization
Suitable Extinguishing Media: Dry chemical, foam, carbon dioxide, water mist for cooling (avoid direct water jet)
Specific Hazards: Gives off toxic fumes including carbon oxides; vapors may form explosive mixtures with air when heated
Special Protective Equipment: Full turnout gear, NIOSH-approved self-contained breathing apparatus
Firefighting Advice: Cool exposed containers with water spray; run-off can pollute water
Decomposition Products: Carbon monoxide, carbon dioxide, acrid smoke and fumes
Personal Precautions: Wear gloves, goggles, chemical-resistant suit; keep unnecessary folks away
Environmental Precautions: Block spills from drains; let local authorities handle big leaks
Cleanup Methods: Absorb liquid with sand or earth, shovel into containers for disposal
Spill Handling: Wash area with detergent and water after cleanup
Handling: Use only where there’s solid airflow; keep containers shut tight; avoid breathing fumes, skin and eye contact; wash up after work
Storage: Keep containers out of sunlight, in a cool, dry spot, away from spark sources; store at 2°C–25°C (36°F–77°F); keep separate from acids, oxidizers, bases; don’t re-use empty containers
Other Precautions: Use inert gas blanketing and light-proof containers for long shelf life
Occupational Exposure Limits: No TLV or PEL assigned for NPGDA; keep acrylic compounds below workplace standards
Ventilation: Fume hood, local exhaust, or plenty of general airflow
Eye Protection: Chemical splash goggles or face shield
Skin Protection: Chemical-resistant gloves (nitrile, neoprene), long sleeves, aprons
Respiratory Protection: NIOSH organic vapor cartridge if vapor build-up happens
Hygiene Measures: No food or drink nearby; wash hands and face after handling
Appearance: Clear, colorless to pale yellow liquid
Odor: Mild ester smell
Molecular Weight: 252.31 g/mol
Boiling Point: 110 - 120°C at 5 mmHg
Flash Point: 105°C (closed cup)
Melting Point: -50°C
Vapor Pressure: < 0.01 mmHg at 25°C
Water Solubility: Slightly soluble
Density: 1.01 – 1.03 g/cm3 at 25°C
Viscosity: 10 – 14 mPa.s at 25°C
Auto-ignition Temp: >200°C
Chemical Stability: Stable under correct storage; will polymerize if heated or exposed to UV or free radicals
Conditions to Avoid: Heat, direct sun, sparks, open flames, static discharge
Incompatible Materials: Strong acids, peroxides, amines, oxidizing agents
Hazardous Decomposition: Carbon monoxide, carbon dioxide, smoke
Polymerization Risks: Rapid exothermic polymerization possible if inhibitors (like MEHQ) depleted
Acute Toxicity: Oral LD50 (rat): 5,000 mg/kg; not acutely toxic by ingestion
Skin Corrosion/Irritation: Skin irritant, can cause redness and dermatitis with repeated contact
Eye Damage/Irritation: Causes eye redness, watering, pain
Respiratory Sensitization: Vapors can trigger throat irritation and coughing
Skin Sensitization: Possible allergic reactions with repeated exposure
Chronic Effects: Risk grows with ongoing contact; eczema or skin allergy possible
Carcinogenicity: Not listed by IARC, NTP, or OSHA as a carcinogen
Mutagenicity / Reproductive Toxicity: No clear evidence from animal data
Aquatic Toxicity: Swimming animals show moderate hazard (fish LC50 10–100 mg/L)
Persistence / Degradability: Not quickly degradable in environment
Bioaccumulation Potential: Low potential for big build-up in aquatic life
Mobility in Soil: Not highly mobile, stuck to particles
Other Harmful Effects: Can damage aquatic life by reducing oxygen if released in bulk
Waste Disposal: Let professionals dispose as hazardous waste by incineration
Contaminated Packaging: Triple rinse; don’t reuse; discard like liquid residue
Legal Compliance: Obey local, state, national waste laws
Special Precautions: Never dump into drains, soil, or natural waters
UN Number: Not classified as dangerous for ADR/RID, IMDG, IATA
Proper Shipping Name: Neopentyl Glycol Diacrylate
Transport Hazard Class: Not a regulated flammable liquid unless it contains extra acrylic acid or lost inhibitor
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant under normal conditions
OSHA: No specific PEL; considered hazardous under Hazard Communication Standard
TSCA: Listed in TSCA inventory
SARA Title III: Not an extremely hazardous substance
California Prop 65: No components listed
REACH: Registered; SDS must be available
Other: Right-to-Know reporting rules apply in some US states
