Product Name: Hydroxypropyl Methacrylate (HPMA)
Chemical Formula: C7H12O3
CAS Number: 27813-02-1
Synonyms: 2-Hydroxypropyl Methacrylate, HPMA, 2-Hydroxy-1-methylethyl methacrylate
Recommended Use: Used in resins, adhesives, coatings, contact lenses, and dental materials
Supplier/Manufacturer: Full address and emergency contact listed with local supplier
Emergency Phone Number: Refer to local directory for 24-hour spill and emergency response
Classification: Eye Irritation (Category 2), Skin Irritation (Category 2), Sensitizer (Category 1), Toxic to aquatic life (Category 3)
GHS Label Elements: Signal word: Warning; Pictograms: Exclamation mark
Hazards: Causes skin irritation, causes serious eye irritation, may cause allergic skin reaction, hazardous to aquatic life with long lasting effects
Precautionary Statements: Avoid breathing vapor or mist; use protective gear; wash hands thoroughly after handling; avoid release into environment
Chemical: Hydroxypropyl Methacrylate
CAS Number: 27813-02-1
Concentration: ≥97% (technical grade)
Impurities: May contain small traces of inhibitors (such as MEHQ), water, other methacrylate monomers in low concentrations
Substances with Workplace Exposure Limits: None assigned specifically to this compound, monitor airborne monomer presence during processing
General Advice: Move affected person away from exposure, remove contaminated clothing immediately
If Inhaled: Move to fresh air, keep comfortable for breathing, seek medical attention if symptoms such as headache or dizziness persist
If on Skin: Wash thoroughly with soap and water, remove contaminated clothes, call for medical attention if redness or irritation remains
If in Eyes: Rinse cautiously with water for several minutes, remove contact lenses if present, continue rinsing, seek eye specialist’s advice if irritation lasts
If Ingested: Rinse mouth thoroughly, do not induce vomiting, get medical support, provide the label or container if possible
Suitable Extinguishing Media: Use alcohol-resistant foam, dry chemical, or carbon dioxide
Unsuitable Media: Avoid strong water jets that may spread burning liquid
Specific Hazards: Vapors may form explosive mixtures with air, hazardous decomposition may release toxic fumes such as carbon monoxide, carbon dioxide, and acrid vapors
Special Protective Equipment: Firefighters must wear full protective clothing including self-contained breathing apparatus
Advice: Evacuate area, cool exposed containers with water, avoid inhaling combustion products
Personal Precautions: Wear chemical-resistant gloves, eye protection, and protective clothing; prevent inhalation of vapors
Environmental Precautions: Prevent spillage from reaching drains or watercourses, report large releases to environmental authorities
Containment Methods: Ventilate area, stop leak if safe, use inert absorbing material (e.g., sand, earth); do not use sawdust or vermiculite
Cleanup Methods: Collect spillage in properly labeled containers for disposal according to local regulations; wash area with detergent and water to remove residues
Safe Handling Tips: Only open containers in well-ventilated areas, avoid skin and eye contact, avoid vapor/mist exposure, wash up after handling
Technical Measures: Ensure proper grounding and bonding where static buildup can occur, use local exhaust ventilation near processing areas
Storage Recommendations: Store in original closed containers away from direct sunlight, heat, oxidizing agents, and acids, maintain below 25°C (77°F), monitor inhibitors
Special Requirements: Label all storage vessels clearly, keep away from food and drink, monitor product for polymerization during long storage, use explosion-proof lighting and electricals where needed
Occupational Exposure Limits: No specific limits established, maintain minimum possible exposure with engineering controls
Engineering Controls: Use process enclosure, local exhaust ventilation, or other engineering controls to control airborne levels
Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), protective goggles, long-sleeved chemical-resistant clothing, face shield for splash risk
Respiratory Protection: Use NIOSH-approved respirators if air concentrations exceed safe levels or in confined spaces
Hygiene Measures: Do not eat, drink, or smoke in handling area; wash hands before breaks and at the end of the workday
Appearance: Colorless or light yellow liquid
Odor: Mild, characteristic acrylic odor
Melting Point: -58°C (-72°F)
Boiling Point: 220°C (428°F)
Flash Point: 99°C (210°F) (closed cup)
Vapor Pressure: <0.1 mmHg (20°C)
Water Solubility: Miscible
Density: 1.03 g/cm³ (20°C)
Partition Coefficient (n-octanol/water): log Kow: 0.97
Viscosity: 5-15 mPa·s (at 25°C)
Other Data: Stable at room temperature in presence of inhibitor; susceptible to light, heat, and contamination by incompatible materials
Chemical Stability: Stable under recommended storage conditions with inhibitors present; can polymerize upon heating or contamination
Possibility of Hazardous Reactions: Polymerizes violently if exposed to heat, light, peroxides, or contaminants
Conditions to Avoid: Heat, ignition sources, direct sunlight, absence of polymerization inhibitor, incompatible materials
Incompatible Materials: Strong acids, strong bases, oxidizers, reducing agents, free radical initiators, amines
Hazardous Decomposition Products: Fumes of carbon monoxide, carbon dioxide, and other toxic gases on burning or decomposition
Acute Toxicity: Oral LD50 (rat): 11200 mg/kg; Dermal LD50 (rabbit): >5000 mg/kg
Skin Contact: Causes significant irritation and possible allergic response following repeated exposure
Eye Contact: Severe irritation, may cause redness, pain, blurred vision
Inhalation: Vapor may cause headaches, dizziness, and respiratory tract irritation
Chronic Exposure: Can cause skin sensitization and allergic eczema after prolonged or repeated contact
Other Effects: Not classified as carcinogenic, mutagenic, or reproductive toxicant at standard exposure levels
Ecotoxicity: Harmful to aquatic organisms at higher concentrations, aquatic invertebrate EC50 (Daphnia magna, 48h): 97 mg/L
Persistence and Degradability: Readily biodegradable, expected to undergo rapid breakdown in aqueous environments
Bioaccumulative Potential: Low potential, log Kow value suggests limited bioaccumulation
Mobility in Soil: Highly mobile in water, risk of groundwater contamination if not contained
Other Information: Prevent releases into the environment, especially waterways; report major spills as per local requirements
Waste Treatment Methods: Incinerate or dispose of through licensed hazardous waste contractor
Product Disposal: Do not release into sewers, drains, or natural water bodies; package waste securely for authorized collection
Contaminated Packaging: Rinse containers, offer for recycling if possible, otherwise dispose of in accordance with regional and national regulations
Other Precautions: Ensure disposal methods minimize environmental impact, retain documentation for all waste movements
UN Number: 1993
UN Proper Shipping Name: Flammable Liquid, n.o.s. (contains Hydroxypropyl Methacrylate)
Transport Hazard Class: 3 (Flammable liquids)
Packing Group: III
Labeling Requirements: Flammable liquid, proper document declaration required
Special Precautions for Transport: Protect from sunlight, avoid temperature extremes, secure containers to prevent tipping or spillage
OSHA Status: Considered hazardous according to OSHA Hazard Communication Standard
TSCA (US): Listed
REACH (EU): Registered, regulatory restrictions apply to use in bulk
SARA Title III: Not listed as an extremely hazardous substance or reportable quantity chemical
WHMIS (Canada): Class B2 (Flammable Liquid), Class D2B (Toxic Material Causing Other Toxic Effects)
Other Regulations: Check local, national, and international regulations for restrictions concerning handling, storage, and disposal
