Product Name: 2-Hydroxyethyl Methacrylate (HEMA)
Synonyms: HEMA, 2-Hydroxyethyl 2-methylpropenoate
Chemical Formula: C6H10O3
Molecular Weight: 130.14 g/mol
CAS Number: 868-77-9
Manufacturer: [Insert supplier company information here—include address, phone number, and emergency contact if available]
Recommended Use: Raw material for dental materials, resins, adhesives, coatings
Restrictions: Only trained personnel should handle large quantities; container labeling clearly marks any restricted areas
Emergency Number: [Insert valid 24-hour emergency contact line]
GHS Classification: Skin Irritant (Category 2), Eye Irritant (Category 2A), Skin Sensitizer (Category 1), Acute Toxicity (Category 4, Oral)
Pictograms: Exclamation mark symbol
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation, may cause allergic skin reaction, harmful if swallowed
Precautionary Statements: Wear protective gloves/eye protection, avoid breathing vapor, wash exposed skin thoroughly after handling, avoid release to the environment
Routes of Exposure: Skin, eyes, inhalation, ingestion
Other Hazards: Vapors can irritate respiratory tract, can polymerize violently if in contact with acids, bases, strong oxidizers, and peroxides
Chemical Name: 2-Hydroxyethyl methacrylate
CAS Number: 868-77-9
Concentration: ≥ 97%
Impurities: May contain trace amounts of ethylene glycol, methacrylic acid, inhibitors (hydroquinone or MEHQ) up to 200 ppm to prevent polymerization
Formulation: Typically found as a colorless, viscous liquid with a sharp odor
Skin Contact: Remove contaminated clothing, immediately wash skin with large amounts of water and mild soap, consult a doctor for severe irritation
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses, keep eyelids open, seek medical attention right away if irritation persists
Inhalation: Move person to fresh air, allow comfortable breathing, seek medical advice if symptoms like coughing or difficulty in breathing occur
Ingestion: Rinse mouth with water, do not induce vomiting, seek medical help directly
Most Important Symptoms/Effects: Redness, swelling, itching on skin; pain, redness, watering in eyes; possible respiratory irritation
Notes for Doctor: Treatment should target symptoms, monitor for allergic response and pulmonary distress
Suitable Extinguishing Media: Dry chemical powder, foam, carbon dioxide (CO2), water spray
Unsuitable Extinguishing Media: Direct water jet (can spread fire or cause splashing)
Hazards from Combustion: Produces carbon oxides (CO, CO2), irritating fumes, possible toxic methacrylate vapor
Protective Equipment: Firefighters should put on full protective gear and self-contained breathing apparatus
Firefighting Instructions: Remove containers from area if safe, cool containers with water, prevent contaminated runoff
Flammability: Liquid and vapor are combustible at high temperatures; keep away from heat and ignition sources
Personal Precautions: Evacuate unprotected people, ventilate area, wear chemical-resistant gloves, safety goggles, and respirator as needed
Spill Cleanup Techniques: Contain spill with sand, earth, or non-combustible absorbent, avoid runoff to drains
Disposal Methods: Scoop and collect absorbed material into labeled containers for disposal, wash area with water and detergent
Environmental Precautions: Stop leaks if safe, prevent spills from entering sewers or waterways
Special Precautions: Clean spill promptly, avoid inhalation of vapors, use spark-proof tools
Precautions for Handling: Avoid contact with skin and eyes, avoid breathing vapors, do not eat, drink, or smoke during use, use only with adequate ventilation
Safe Storage Conditions: Store in tightly sealed original containers in a cool, well-ventilated place away from heat, sunlight, and sources of ignition; temperature recommendations usually below 30°C; maintain inhibitor presence to prevent polymerization
Incompatible Materials: Acids, strong oxidizing agents, peroxides, free radical initiators—which can trigger uncontrolled polymerization
Storage Life: Storable for 6 to 12 months under recommended conditions; check containers for buildup of pressure or distortion
Occupational Exposure Limits: OSHA, NIOSH, and ACGIH do not list a specific PEL, but controlling exposure by engineering practices is important
Engineering Controls: Use local exhaust ventilation, closed systems
Personal Protective Equipment: Nitrile or neoprene gloves, chemical splash goggles or face shield, lab coat, suitable respirator if ventilation stands poor
Hygiene: Wash hands thoroughly after handling, avoid skin contact, change out of contaminated clothing immediately
Environmental Controls: Prevent chemical from entering drains or waterways, use spill trays or secondary containment in work areas
Physical State: Liquid
Appearance: Colorless to yellowish, viscous
Odor: Slight, sweet, acrid scent
Odor Threshold: Low, detectable at concentrations below permissible limits
pH: Not applicable
Melting Point: -12 °C
Boiling Point: 213 °C
Flash Point: 97 °C (Closed Cup)
Evaporation Rate: Slower than water
Flammability: Combustible liquid
Vapor Pressure: 0.03 mm Hg at 20°C
Vapor Density: 4.5 (air = 1)
Relative Density: 1.07 g/cm³
Solubility: Miscible with water, soluble in most organic solvents
Partition Coefficient (log Kow): 0.42
Auto-ignition Temperature: 415 °C
Decomposition Temperature: Not specified
Viscosity: 7-12 mPa·s (at 20°C)
Chemical Stability: Stable with the addition of inhibitor (e.g. MEHQ, hydroquinone); without inhibitor, sensitive to heat, light, or contaminants
Polymerization: May occur at elevated temperature or with incompatible materials, releasing heat
Conditions to Avoid: Elevated temperatures, light, contamination by strong acids, bases, or oxidizers
Incompatible Materials: Free radical initiators, iron, rust, peroxides, strong acids and alkalis
Hazardous Decomposition Products: Carbon monoxide, carbon dioxide, acrid vapors
Acute Toxicity: LD50 (oral, rat): 5,052 mg/kg; LD50 (dermal, rabbit): > 3,000 mg/kg
Skin Effects: Causes irritation; repeated exposure may cause dermatitis or allergic reactions
Eye Effects: Causes irritation; contact causes redness, pain, and swelling
Respiratory: Vapors may cause respiratory tract irritation; high doses can cause headaches, dizziness, or drowsiness
Chronic Effects: Sensitization with repeated skin contact, possible occupational asthma
Carcinogenicity: Not classified as carcinogenic by IARC, NTP, OSHA
Mutagenicity / Teratogenicity: No conclusive evidence for mutagenic or teratogenic effects reported
Other Information: Prolonged or repeated exposure can exacerbate skin and eye injury
Aquatic Toxicity: LC50 for fish (Oncorhynchus mykiss, 96h): 227 mg/L
Biodegradability: Biodegradable under aerobic conditions, but persistent in poorly aerated waters
Bioaccumulation: Low potential, log Kow suggests minimal accumulation in aquatic organisms
Mobility in Soil: Mobile, can migrate to groundwater but rapidly degraded in exposed environments
Other Hazards: Does not undergo significant atmospheric degradation
Ecotoxicological Notes: High concentrations may affect aquatic life by reducing oxygen transfer, but practical use rarely leads to such levels due to good solubility and dilution
Disposal Methods: Dispose of contents and container in compliance with local, regional and national regulations; incinerate at high temperature with appropriate emission controls
Contaminated Packaging: Rinse and recycle if possible, otherwise dispose as hazardous waste
Special Precautions: Do not pour into drains, surface water, or soil; keep waste separate and clearly labeled
Recommended Waste Codes: Use codes for spent organic chemicals (such as US EPA D001 if flammable)
UN Number: UN 1993
UN Proper Shipping Name: Flammable Liquid, N.O.S. (Hydroxyethyl Methacrylate)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III
Environmental Hazard: Not listed as marine pollutant
Special Precautions: Ensure closures are secure, containers upright, segregate from incompatible cargo
Additional Info: Emergency procedures in place required for spills and fire incidents during transport
US Regulations (OSHA, TSCA): Listed in TSCA inventory, not subject to specific OSHA PSM, SARA 313 reporting exempt
EU Regulations (REACH, CLP): Registered under REACH, classified for skin, eye, and respiratory irritation, subject to workplace labeling
Canada (DSL/NDSL): DSL listed
Labeling Requirements: Conspicuous hazard symbols, risk and safety phrases in all work areas
Other Country-Specific Notes: Consult relevant national chemical safety agencies for further requirements; keep up-to-date with changes in permissible exposure limits or banned uses
