Product Name: 4-Nitroaniline (PNA)
Chemical Formula: C6H6N2O2
Synonyms: para-Nitroaniline, p-Nitroaniline
CAS Number: 100-01-6
Recommended Use: Laboratory reagent, intermediate in dye manufacturing
Supplier: [Supplier Name and Contact Details]
Emergency Phone: [Insert local emergency contact]
Hazard Class: Acute Toxicity (Oral, Dermal, Inhalation), Eye Irritation, Skin Sensitization
Signal Word: Danger
Hazard Statements: Harmful if swallowed, Toxic in contact with skin, Causes skin and eye irritation, May cause allergic skin reaction
Pictograms: Skull and Crossbones, Exclamation Mark
Precautionary Statements: Do not breathe dust, Wear protective gloves and clothing, Wash hands thoroughly after handling, Contaminated work clothing should not be allowed out of the workplace
Chemical Name: 4-Nitroaniline
Concentration: ≥ 99%
Impurities: Trace undetected (<0.1%), typically includes other nitroanilines and byproducts from synthesis
Molecular Weight: 138.13 g/mol
Inhalation: Move person to fresh air, seek immediate medical attention if breathing difficulty persists
Skin Contact: Remove contaminated clothing, rinse skin thoroughly with water for at least 15 minutes, medical attention required
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present, keep eyes open, immediate medical care
Ingestion: Do NOT induce vomiting, rinse mouth with water, medical attention immediately required
Symptoms: Cyanosis, headache, dizziness, nausea, skin staining, difficulty breathing in severe exposures
Suitable Extinguishing Media: Dry chemical powder, CO2, foam, water spray
Unsuitable Media: Solid water streams risk spreading material
Hazardous Combustion Products: Nitrogen oxides, carbon monoxide, carbon dioxide, toxic smoke
Special Equipment: Firefighters should wear full protective gear and self-contained breathing apparatus
Additional Advice: Remove containers from fire area if safe, prevent runoff from contaminating water supplies
Personal Precautions: Avoid breathing dust, use appropriate personal protective equipment, ensure adequate ventilation
Environmental Precautions: Prevent entry into water bodies, drains, and soil
Methods for Cleanup: Sweep up carefully, avoid generation of dust, collect in suitable closed containers, dispose in accordance with local regulations, decontaminate area with detergent
Emergency Procedures: Evacuate area, restrict access until cleanup complete
Spill Reporting: Notify local health, safety, and environmental authorities if required
Handling: Use only in well-ventilated areas, avoid skin and eye contact, do not eat, drink, or smoke when handling, wash hands before breaks and after work
Storage: Store in cool, dry location, away from incompatible substances such as strong oxidizing agents and reducers, keep container tightly closed, clearly labeled
Storage Conditions: Protect from direct sunlight, moisture, and extreme temperatures, use secondary containment for large amounts, secure storage against unauthorized access
Occupational Exposure Limits: ACGIH TLV: 5 mg/m3 (skin), OSHA PEL: Not established
Engineering Controls: Fume hood or local exhaust ventilation to minimize airborne concentrations
Personal Protection: Chemical-resistant gloves (nitrile or butyl rubber), splash goggles, laboratory coat, respiratory protection (NIOSH-approved respirator) if dust present
Hygiene Measures: Remove contaminated clothing after work, do not eat or drink in work areas, thorough washing after handling
Appearance: Yellow to light brown crystalline solid
Odor: Slightly aromatic
Melting Point: 146–149°C
Boiling Point: 332°C (decomposes)
Solubility: Practically insoluble in water, soluble in ethanol and ether
Vapor Pressure: Negligible at 20°C
Density: 1.437 g/cm3 at 20°C
Flash Point: >200°C
pH: Not applicable
Partition Coefficient (log Kow): 1.06
Other Properties: Forms toxic dust, will stain materials and skin
Chemical Stability: Stable under recommended storage conditions
Reactivity: May react with reducing agents, strong acids, and bases
Incompatible Materials: Strong oxidizing agents, reducing agents, chlorates, nitrates
Hazardous Decomposition Products: Nitrogen oxides, carbon oxides, potentially toxic fumes under fire or strong heat
Polymerization: Will not undergo hazardous polymerization
Routes of Exposure: Inhalation, skin absorption, ingestion, eye contact
Acute Toxicity: LD50 (oral, rat): 750 mg/kg; LD50 (dermal, rabbit): 1200 mg/kg
Chronic Effects: Methemoglobinemia, anemia, liver and kidney damage with high or repeated exposure
Symptoms: Nausea, headache, dizziness, impaired breathing, skin and eye irritation, cyanosis due to hindered oxygen transport
Mutagenicity/Carcinogenicity: Limited data, not listed as carcinogen by IARC, NTP, OSHA, but caution advised
Ecotoxicity: Harmful to aquatic life, toxic to fish and invertebrates
Persistence and Degradability: Slowly biodegradable, can persist in environment
Bioaccumulation Potential: Low to moderate based on log Kow value
Mobility in Soil: Moderate, may contaminate groundwater
Other Adverse Effects: Risk of water contamination if released in significant quantities, avoid release to the environment
Waste Disposal: Dispose through licensed chemical waste contractor, in accordance with local, regional, and national regulations
Contaminated Packaging: Dispose as unused product, triple rinse containers, remove labels before disposal
Precautions: Do not pour chemicals into drains, water sources, or soil
RCRA Status: Check for classification under hazardous waste regulations
UN Number: UN1661
Proper Shipping Name: 4-Nitroaniline
Hazard Class: 6.1 (Toxic Substance)
Packing Group: III
Labels Required: Toxic (6.1, Skull and Crossbones symbol)
Environmental Hazards: Marine pollutant
Special Precautions: Provide suitable containment, documentation, and emergency response information during transport
OSHA: Regulated hazardous chemical
TSCA: Listed on U.S. TSCA inventory
REACH: Registered for manufacture and use in industrial applications, restrictions apply
SARA Title III: Section 313 (toxic chemical)
DSL/NDSL (Canada): Listed
International Inventories: EINECS (Europe): 202-816-5, other relevant country-specific regulations may apply
Label Elements: Hazard symbol, signal word, risk and safety phrases as required by jurisdiction
Other Regulation Notes: Consult local environmental protection guidelines and safety legislation for additional information
