Product Name: 2,2,3,3-Tetrafluoropropyl Methacrylate
Synonyms: Methacrylic acid 2,2,3,3-tetrafluoropropyl ester
CAS Number: 451-86-1
Recommended Use: Specialty monomer in polymer synthesis
Supplier: Chemical specialty providers and research chemical suppliers; specific name and address as supplied with shipment
Emergency Contact: Refer to manufacturer’s emergency number on shipping documents
Contact for Information: Product safety department, phone number and e-mail as per shipment paperwork
Classification (GHS): Flammable liquid (Category 3), Skin irritant (Category 2), Eye irritant (Category 2A), Specific target organ toxicity – single exposure (Category 3, respiratory tract)
Signal Word: Warning
Hazard Statements: Causes skin and eye irritation. May cause respiratory irritation. Flammable liquid and vapor.
Pictograms: Flame, exclamation mark
Precautionary Statements: Keep away from heat and open flames. Avoid breathing vapors. Use personal protective equipment. Wash thoroughly after handling.
Unusual Hazards: Vapors heavier than air. Can accumulate in low spots, displacing oxygen.
Chemical Identity: 2,2,3,3-Tetrafluoropropyl Methacrylate
CAS Number: 451-86-1
Concentration: Greater than 99% as supplied
Impurities: Trace stabilizers (inhibitors such as MEHQ or hydroquinone mono-methyl ether, typically <200 ppm to prevent polymerization), trace residual solvents (<1%)
Other Ingredients: No significant additional substances present above reporting thresholds
Inhalation: Move to fresh air. Seek medical help if symptoms persist or breathing becomes difficult. Administer oxygen if available and trained.
Skin Contact: Wash affected area thoroughly with soap and water. Remove contaminated clothing and shoes. Get medical advice if irritation develops.
Eye Contact: Rinse cautiously with water for at least 15 minutes. Remove contact lenses if present and easy to do. Seek prompt attention if irritation or pain persists.
Ingestion: Rinse mouth. Do not induce vomiting. Give water to drink only if conscious. Seek immediate medical assistance.
Most Important Symptoms or Effects, Acute and Delayed: Irritation of eyes, skin, and respiratory system. Prolonged exposure can aggravate symptoms. Central nervous system effects possible from overexposure (dizziness, headache).
Suitable Extinguishing Media: Dry chemical, alcohol-resistant foam, carbon dioxide, water spray for cooling
Unsuitable Extinguishing Media: Direct water jet (may spread fire)
Specific Hazards: Vapors may form explosive mixtures with air. Combustion yields toxic fumes including carbon oxides and hydrogen fluoride.
Protective Equipment for Firefighters: Full protective gear and self-contained breathing apparatus (SCBA)
Special Precautions: Cool exposed containers with water mist to prevent rupture. Evacuate area and prevent runoff from entering drains.
Personal Precautions: Evacuate unnecessary personnel. Avoid breathing vapors. Wear protective clothing, gloves, goggles, and respirator if ventilation is inadequate.
Environmental Precautions: Prevent product from entering drains or watercourses. Notify authorities if significant spills reach the environment.
Containment and Cleanup Methods: Eliminate ignition sources. Contain with inert absorbent (sand, earth, vermiculite). Sweep or scoop into labeled waste containers. Dispose of in accordance with regulations. Ventilate area after cleanup.
Safe Handling Advice: Use only in well-ventilated areas. Avoid skin and eye contact. Avoid inhalation of vapors or mists. Ground containers when transferring.
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated place away from heat and direct sunlight. Store inhibitor-stabilized. Keep away from oxidizing agents and incompatibles.
Storage Stability: Product may polymerize if deprived of inhibitor, heated, or exposed to light.
Other Information: Regularly check inhibitor levels and container integrity.
Occupational Exposure Limits: No specific national limits established for this compound; use generic solvent vapor limits as guidance.
Engineering Controls: Use fume hood or effective local exhaust ventilation. Ensure showers and eyewash stations available in areas of use.
Personal Protective Equipment: Chemical-resistant gloves (nitrile), safety goggles, face shield for large quantities, impermeable apron or lab coat, respiratory protection if vapor concentrations approach limits.
Hygiene Measures: Wash hands thoroughly after handling. Remove contaminated clothing. Do not eat, drink, or smoke during use.
Appearance: Clear, colorless to slightly yellow liquid
Odor: Slight, acrid
pH: Not applicable (neutral organic liquid)
Melting Point: Approximately -60°C
Boiling Point: 92-95°C at atmospheric pressure
Flash Point: ~32°C (closed cup)
Evaporation Rate: Moderate (comparable to similar methacrylates)
Flammability: Flammable liquid and vapor
Vapor Pressure: 45-55 mmHg at 25°C
Vapor Density: Heavier than air
Relative Density: ~1.25-1.35 (water = 1)
Solubility: Insoluble in water; miscible with most organic solvents
Partition Coefficient: Not determined
Auto-Ignition Temperature: Not precisely determined (estimate: 230°C)
Decomposition Temperature: Above 150°C produces toxic gases
Viscosity: Low viscosity liquid at room temperature
Chemical Stability: Stable under recommended storage conditions and in presence of stabilizer.
Possibility of Hazardous Reactions: May undergo exothermic polymerization lacking stabilizer or under heat, light, or contact with initiators.
Conditions to Avoid: Heat, direct sunlight, absence of inhibitor, contamination with peroxides, strong acids/bases.
Incompatible Materials: Strong oxidizers, acids, peroxides, amines, reducing agents.
Hazardous Decomposition Products: Carbon oxides, hydrogen fluoride, toxic fluorinated compounds.
Routes of Exposure: Vapors inhaled, skin or eye contact, ingestion
Acute Toxicity: Data limited; expected to show moderate to low toxicity based on chemical class; no reported human poisoning case. Vendors report oral LD50 (rat) > 1000 mg/kg.
Skin Corrosion/Irritation: Causes skin irritation based on structure and experience with similar esters.
Serious Eye Damage/Irritation: Causes moderate to severe eye irritation.
Respiratory/Skin Sensitization: May cause allergic reaction in sensitive individuals, as with other methacrylates.
Repeated Dose Toxicity: Not fully studied; possible respiratory system or organ impact from repeated high exposure.
Carcinogenicity, Mutagenicity, Reproductive Toxicity: Not classified; insufficient data for formal risk assessment.
Symptoms and Effects: Redness, itching, pain at exposed sites, respiratory discomfort, rare risk of central nervous depression with high vapor exposure.
Ecotoxicity: Moderately toxic to aquatic organisms based on analogous fluorinated methacrylates.
Persistence and Degradability: Slowly biodegradable; fluorinated fragment adds persistence.
Bioaccumulative Potential: Moderate potential for bioaccumulation in aquatic systems.
Mobility in Soil: Likely to partition to organic fraction, possible to leach with surface runoff depending on formulation.
Other Adverse Effects: No known ozone depletion potential. Breakdown may generate persistent fluorinated species.
Product Disposal: Send to licensed chemical disposal facility. Do not release into sewers or drains. Incinerate with appropriate scrubbing/abatement for fluorinated waste.
Contaminated Packaging: Triple rinse, puncture, and dispose of as hazardous waste.
Other Waste: Small amounts can be absorbed and sent for disposal as chemical waste if allowed by regulations.
Regulatory Waste Classification: US RCRA hazardous waste for flammable solvents; EU hazardous waste code for organic solvents with halogens.
UN Number: UN 1993
Proper Shipping Name: Flammable Liquid, N.O.S. (Contains 2,2,3,3-Tetrafluoropropyl Methacrylate)
Transport Hazard Class: 3 (Flammable Liquid)
Packing Group: III (Medium hazard)
Environmental Hazards: Not a marine pollutant under IMDG, but check with specific carrier
Special Precautions: Avoid release. Ensure labeling and documentation match shipment contents.
US TSCA Status: Listed or subject to exemption
EU REACH Status: Registration required for commercial quantities; check local status
Symbols and Risk Phrases (EU): F – Flammable; Xi – Irritant; R10 – Flammable, R36/37/38 – Irritating to eyes, respiratory system and skin
Regulatory References: OSHA Hazard Communication Standard; EU CLP Regulation (EC) No 1272/2008
Other Regulations: Check national inventories for status in non-US/EU jurisdictions. Transport and workplace safety rules apply for flammable liquids.
