Product Name: 2,2,2-Trifluoroethyl Methacrylate
Chemical Formula: C6H7F3O2
Synonyms: TFEMA, Trifluoroethyl Methacrylate
CAS Number: 352-87-4
Use: Intermediate in polymer synthesis, copolymer production
Manufacturer: Supplier contact details required for chemical ordering, check label or procurement records
Emergency Phone: Check label, supplier contact information, or local poison control center
Recommended Restrictions: For industrial or laboratory use only, not for food, drug, or household applications
GHS Classification: Flammable Liquids (Category 3), Skin Irritant (Category 2), Eye Irritant (Category 2), Specific Target Organ Toxicity - Single Exposure (Category 3, respiratory tract irritation)
Signal Word: Warning
Hazard Statements: H226 (Flammable liquid and vapor), H319 (Causes serious eye irritation), H315 (Causes skin irritation), H335 (May cause respiratory irritation)
Pictograms: Flame, Exclamation Mark
Precautionary Statements: Avoid breathing vapors, use only outdoors or in well-ventilated areas, keep away from heat/sparks/open flames, wear protective gloves and eye protection, wash hands thoroughly after handling, store in tightly closed container
Chemical Name: 2,2,2-Trifluoroethyl Methacrylate
CAS Number: 352-87-4
Concentration: Typically >98% by weight
Impurities: Inhibitor for polymerization (often <0.1% hydroquinone or similar stabilizer)
Other Components: Trace stabilizers only, not present in significant amounts
Inhalation: Move person to fresh air, support breathing with oxygen if needed, consult physician if breathing problems develop
Skin Contact: Take off contaminated clothing, wash skin thoroughly with soap and water, seek medical advice if symptoms persist
Eye Contact: Rinse cautiously with water for several minutes, remove contact lenses if present and easy to do, seek medical attention for persistent irritation
Ingestion: Rinse mouth, never give anything by mouth if unconscious, seek immediate medical aid, do not induce vomiting unless directed by medical personnel
Symptoms: Redness, irritation, cough, dizziness, burning sensation of skin and eyes, respiratory discomfort
Suitable Extinguishing Media: Carbon dioxide, dry chemical powder, foam, water spray
Unsuitable Extinguishing Media: Direct water jet may spread liquid fire
Hazardous Combustion Products: Hydrogen fluoride, carbon oxides, organic vapors
Specific PPE for Firefighters: Self-contained breathing apparatus, chemical protective clothing
Special Firefighting Procedures: Cool containers with water from safe distance, avoid inhaling smoke, evolutionary fumes may be highly irritant or toxic
Personal Precautions: Evacuate area, ventilate, avoid breathing vapors, use protective equipment including gloves and chemical goggles
Environmental Precautions: Prevent entry into drains, surface water, and soil, notify authorities if product contaminates environment
Spill Cleanup Methods: Absorb with inert material (sand, vermiculite), collect in chemical waste container, clean spill area with water and detergent, provide adequate ventilation during cleanup
Disposal: See Section 13 for proper wasted chemical disposal
Handling: Use only in well-ventilated areas, avoid contact with skin, eyes, and clothing, do not breathe vapors, ground containers during liquid transfer
Storage: Store in tightly closed original container in a cool, dry, well-ventilated place away from incompatible materials such as oxidizing agents and acids, keep out of direct sunlight, storage temperature recommended: 2–8°C (refrigerated conditions)
Incompatibilities: Strong acids, strong oxidizers, strong bases, metal powders, initiators that could start unwanted polymerization
Packing Materials: Compatible with HDPE, glass, stainless steel; avoid metals prone to corrosion or decomposition
Exposure Limits: No specific OSHA or ACGIH exposure limits established for this substance
Engineering Controls: Local exhaust ventilation, chemical fume hood recommended
Personal Protective Equipment (PPE): Chemical-resistant gloves (nitrile or neoprene), safety goggles or face shield, flame-retardant lab coat or chemical apron
Respiratory Protection: NIOSH/MSHA approved organic vapor respirator if ventilation is inadequate or occupational exposure risk exists
Hygiene Measures: Wash hands after handling, avoid eating, drinking, or smoking in work areas, remove contaminated clothing and PPE before leaving laboratory or workplace
Appearance: Colorless to pale yellow liquid
Odor: Acrid, pungent odor
Molecular Weight: 168.12 g/mol
Boiling Point: 91–94°C at 760 mmHg
Melting Point: Typically below -60°C
Flash Point: 25–30°C (CC)
Flammability: Readily flammable
Vapor Pressure: 45 mmHg at 25°C
Solubility: Insoluble in water, miscible with organic solvents like ethanol and acetone
Density: 1.174 g/cm³ at 20°C
Auto-Ignition Temperature: Not well documented; handle as potentially low
Partition Coefficient (log Kow): Estimated 2.2–2.8
pH: Not applicable (neutral organic liquid)
Chemical Stability: Stable under recommended storage conditions and in presence of inhibitor
Polymerization: May undergo hazardous polymerization if contaminated or heated above recommended storage temperature, or upon exposure to light or peroxides
Incompatible Materials: Acids, bases, oxidizers, reducing agents, peroxides, strong light or heat
Hazardous Decomposition Products: Hydrogen fluoride, carbon monoxide, carbon dioxide, toxic organic vapors
Conditions to Avoid: Heat, light, contamination by metals or reducing agents, absence of stabilizer
Acute Toxicity: Data limited; estimated oral LD50 (rat) >2000 mg/kg, inhalation: irritant to mucous membranes
Skin Corrosion/Irritation: Moderate to strong skin irritant, may cause redness, burns on prolonged or repeated exposure
Serious Eye Damage/Irritation: Causes severe eye irritation, possible burns and injury
Respiratory Sensitization: Can irritate respiratory tract on inhalation, coughing, shortness of breath reported in exposed workers
Carcinogenicity: Not classified as carcinogen by IARC, NTP, or OSHA
Mutagenicity/Reproductive Toxicity: No sufficient data from animal experiments, potential not fully investigated, prudent to minimize unnecessary exposure
Repeated Dose Toxicity: May cause skin and eye irritation, chronic respiratory symptoms if inhaled repeatedly at high levels
Other Effects: Central nervous system effects (headache, dizziness) possible at high exposure; solvent abuse not reported
Ecotoxicity: Harmful to aquatic life; avoid uncontrolled release to environment
Persistence & Degradability: Not highly biodegradable, limited data but likely to persist under normal environmental conditions
Bioaccumulation: Potential for bioaccumulation based on log Kow values, limited direct studies
Mobility in Soil: Moderately mobile; spills may leach if not contained
Other Adverse Effects: Avoid release to surface waters, long-term effects in aquatic ecosystems not fully quantified
Waste Treatment Methods: Dispose in accordance with local, regional, and national laws, incinerate with flue gas scrubbing if available
Contaminated Packaging: Empty containers should be rinsed, punctured, and rendered unusable before disposal; manage as hazardous waste
Precautions for Disposal: Avoid release to environment, do not pour down drain, label all waste containers clearly, check with authorized chemical waste contractors for pick-up
UN Number: UN 1993
UN Proper Shipping Name: Flammable Liquid, N.O.S. (2,2,2-Trifluoroethyl Methacrylate)
Transport Hazard Class: 3 (Flammable liquid)
Packing Group: III (moderate hazard)
Environmental Hazards: Not a marine pollutant by GHS GHS/IMDG definitions, but leaks must be reported
Special Precautions: Keep away from sources of ignition during transport, restrict movement of containers in vehicle, maintain upright and secure positioning at all times
TSCA Status (USA): Listed on the Toxic Substances Control Act (TSCA) Inventory
REACH Status (EU): Registered, check specific supplier dossier for compliance
Other National Inventories: Included in Canadian DSL, Australian AICS, Japanese ENCS, Korean ECL, and Chinese IECSC
OSHA Hazards: Flammable liquid, skin and eye irritant, respiratory tract irritant
Label Information: Must include GHS signal word, hazard statements, precautionary statements, and pictograms as described
EPA SARA Title III: Listed as hazardous based on flammability and irritant properties
California Prop 65: Not listed for cancer or reproductive toxicity (subject to updates)
